Ontology highlight
ABSTRACT:
SUBMITTER: Gerashchenko MV
PROVIDER: S-EPMC3491468 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Gerashchenko Maxim V MV Lobanov Alexei V AV Gladyshev Vadim N VN
Proceedings of the National Academy of Sciences of the United States of America 20121008 43
Information on unique and coordinated regulation of transcription and translation in response to stress is central to the understanding of cellular homeostasis. Here we used ribosome profiling coupled with next-generation sequencing to examine the interplay between transcription and translation under conditions of hydrogen peroxide treatment in Saccharomyces cerevisiae. Hydrogen peroxide treatment led to a massive and rapid increase in ribosome occupancy of short upstream ORFs, including those w ...[more]