Ontology highlight
ABSTRACT:
SUBMITTER: Ito S
PROVIDER: S-EPMC3491567 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ito Shinsuke S D'Alessio Ana C AC Taranova Olena V OV Hong Kwonho K Sowers Lawrence C LC Zhang Yi Y
Nature 20100801 7310
DNA methylation is one of the best-characterized epigenetic modifications. Although the enzymes that catalyse DNA methylation have been characterized, enzymes responsible for demethylation have been elusive. A recent study indicates that the human TET1 protein could catalyse the conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC), raising the possibility that DNA demethylation may be a Tet1-mediated process. Here we extend this study by demonstrating that all three mous ...[more]