Unknown

Dataset Information

0

Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapy.


ABSTRACT:

Background

Response rates and immunologic memory following measles vaccination are reduced in human immunodeficiency virus (HIV)-infected children in the absence of highly active antiretroviral therapy (HAART).

Methods

HIV-infected children 2 to <19 years old receiving HAART and with HIV loads <30,000 copies/mL, CD4% ≥15, and ≥1 prior measles-mumps-rubella vaccination (MMR) were given another MMR. Measles antibody concentrations before and 8, 32, and 80 weeks postvaccination were determined by plaque reduction neutralization (PRN). A subset was given another MMR 4-5 years later, and PRN antibody was measured before and 7 and 28 days later.

Results

At entry, 52% of 193 subjects were seroprotected (PRN ≥120 mIU/mL). Seroprotection increased to 89% 8 weeks postvaccination, and remained at 80% 80 weeks postvaccination. Of 65 subjects revaccinated 4-5 years later, 85% demonstrated memory based on seroprotection before or 7 days after vaccination. HIV load ≤400 copies/mL at initial study vaccination was associated with higher seroprotection rates, greater antibody concentrations, and memory. Grade 3 fever or fatigue occurred in 2% of subjects.

Conclusions

Measles revaccination induced high rates of seroprotection and memory in children receiving HAART. Both endpoints were associated with HIV viral load suppression.

Clinical trials registration

NCT00013871 (www.clinicaltrials.gov).

SUBMITTER: Abzug MJ 

PROVIDER: S-EPMC3491735 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapy.

Abzug Mark J MJ   Qin Min M   Levin Myron J MJ   Fenton Terence T   Beeler Judy A JA   Bellini William J WJ   Audet Susette S   Sowers Sun Bae SB   Borkowsky William W   Nachman Sharon A SA   Pelton Stephen I SI   Rosenblatt Howard M HM  

The Journal of infectious diseases 20120612 4


<h4>Background</h4>Response rates and immunologic memory following measles vaccination are reduced in human immunodeficiency virus (HIV)-infected children in the absence of highly active antiretroviral therapy (HAART).<h4>Methods</h4>HIV-infected children 2 to <19 years old receiving HAART and with HIV loads <30,000 copies/mL, CD4% ≥15, and ≥1 prior measles-mumps-rubella vaccination (MMR) were given another MMR. Measles antibody concentrations before and 8, 32, and 80 weeks postvaccination were  ...[more]

Similar Datasets

| S-EPMC2814776 | biostudies-literature
| S-EPMC3825555 | biostudies-literature
| S-EPMC2981867 | biostudies-literature
| S-EPMC2603626 | biostudies-literature
| S-EPMC2446619 | biostudies-literature
| S-EPMC5853506 | biostudies-literature
| S-EPMC6553903 | biostudies-literature
| S-EPMC2818410 | biostudies-literature
| S-EPMC7446831 | biostudies-literature
| S-EPMC4565655 | biostudies-literature