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Hairless promotes PPAR? expression and is required for white adipogenesis.

ABSTRACT: Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPAR?, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.

SUBMITTER: Kumpf S

PROVIDER: S-EPMC3492706 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Hairless promotes PPARγ expression and is required for white adipogenesis.

Kumpf Susann S Mihlan Michael M Goginashvili Alexander A Grandl Gerald G Gehart Helmuth H Godel Aurélie A Schmidt Juliane J Müller Julius J Bezzi Marco M Ittner Arne A Guccione Ernesto E Wolfrum Christian C Ricci Romeo R

EMBO reports 20120911 11

Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the ...[more]

PMID: 22964757

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