Ontology highlight
ABSTRACT:
SUBMITTER: Xin HW
PROVIDER: S-EPMC3492937 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Stem cells (Dayton, Ohio) 20120401 4
Label-retaining cells (LRCs) have been proposed to represent adult tissue stem cells. LRCs are hypothesized to result from either slow cycling or asymmetric cell division (ACD). However, the stem cell nature and whether LRC undergo ACD remain controversial. Here, we demonstrate label-retaining cancer cells (LRCCs) in several gastrointestinal (GI) cancers including fresh surgical specimens. Using a novel method for isolation of live LRCC, we demonstrate that a subpopulation of LRCC is actively di ...[more]