Ontology highlight
ABSTRACT:
SUBMITTER: Hu HY
PROVIDER: S-EPMC3493648 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Nature communications 20120101
MicroRNA-mediated gene regulation is important in many physiological processes. Here we explore the roles of a microRNA, miR-941, in human evolution. We find that miR-941 emerged de novo in the human lineage, between six and one million years ago, from an evolutionarily volatile tandem repeat sequence. Its copy-number remains polymorphic in humans and shows a trend for decreasing copy-number with migration out of Africa. Emergence of miR-941 was accompanied by accelerated loss of miR-941-binding ...[more]