Ontology highlight
ABSTRACT:
SUBMITTER: Kim IH
PROVIDER: S-EPMC3493966 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Kim Il Hwan IH Carlson Benjamin R BR Heindel Clifford C CC Kim Hyun H Soderling Scott H SH
The Journal of biological chemistry 20120924 46
Hydrocephalus is the most common developmental disability and leading cause of brain surgery for children. Current treatments are limited to surgical intervention, as the factors that contribute to the initiation of hydrocephalus are poorly understood. Here, we describe the development of obstructive hydrocephalus in mice that are null for Wrp (Srgap3). Wrp is highly expressed in the ventricular stem cell niche, and it is a gene required for cytoskeletal organization and is associated with syndr ...[more]