Ontology highlight
ABSTRACT:
SUBMITTER: Janssens M
PROVIDER: S-EPMC3494247 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Janssens Michelle M van Smeden Jeroen J Gooris Gert S GS Bras Wim W Portale Guiseppe G Caspers Peter J PJ Vreeken Rob J RJ Hankemeier Thomas T Kezic Sanja S Wolterbeek Ron R Lavrijsen Adriana P AP Bouwstra Joke A JA
Journal of lipid research 20120928 12
A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in the pathogenesis of AE. Nevertheless, the precise causes of AE-associated barrier dysfunction are largely unknown. In this study, a comprehensive analysis of ceramide composition and lipid organizati ...[more]