Ontology highlight
ABSTRACT:
SUBMITTER: Ikei KN
PROVIDER: S-EPMC3494251 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ikei Kenneth N KN Yeung Jennifer J Apopa Patrick L PL Ceja Jesús J Vesci Joanne J Holman Theodore R TR Holinstat Michael M
Journal of lipid research 20120913 12
Human platelet-type 12-lipoxygenase (12-LOX) has recently been shown to play an important role in regulation of human platelet function by reacting with arachidonic acid (AA). However, a number of other fatty acids are present on the platelet surface that, when cleaved from the phospholipid, can be oxidized by 12-LOX. We sought to characterize the substrate specificity of 12-LOX against six essential fatty acids: AA, dihomo-γ-linolenic acid (DGLA), eicosapentaenoic acid (EPA), α-linolenic acid ( ...[more]