Snail1 controls TGF-? responsiveness and differentiation of mesenchymal stem cells.
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ABSTRACT:
SUBMITTER: Batlle R
PROVIDER: S-EPMC3494751 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells.
Batlle R R Alba-Castellón L L Loubat-Casanovas J J Armenteros E E Francí C C Stanisavljevic J J Banderas R R Martin-Caballero J J Bonilla F F Baulida J J Casal J I JI Gridley T T García de Herreros A A
Oncogene 20120806 28
The Snail1 transcriptional repressor plays a key role in triggering epithelial-to-mesenchymal transition. Although Snail1 is widely expressed in early development, in adult animals it is limited to a subset of mesenchymal cells where it has a largely unknown function. Using a mouse model with inducible depletion of Snail1, here we demonstrate that Snail1 is required to maintain mesenchymal stem cells (MSCs). This effect is associated to the responsiveness to transforming growth factor (TGF)-β1 t ...[more]
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