Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3494854 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Chen Jing J Nekrasova Oxana E OE Patel Dipal M DM Klessner Jodi L JL Godsel Lisa M LM Koetsier Jennifer L JL Amargo Evangeline V EV Desai Bhushan V BV Green Kathleen J KJ
The Journal of cell biology 20121105 4
Desmosomal cadherins, desmogleins (Dsgs) and desmocollins, make up the adhesive core of intercellular junctions called desmosomes. A critical determinant of epithelial adhesive strength is the level and organization of desmosomal cadherins on the cell surface. The Dsg subclass of desmosomal cadherins contains a C-terminal unique region (Dsg unique region [DUR]) with unknown function. In this paper, we show that the DUR of Dsg2 stabilized Dsg2 at the cell surface by inhibiting its internalization ...[more]