Ontology highlight
ABSTRACT:
SUBMITTER: Yin L
PROVIDER: S-EPMC3494899 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Yin Lei L Crawford Frances F Marrack Philippa P Kappler John W JW Dai Shaodong S
Proceedings of the National Academy of Sciences of the United States of America 20121022 45
T cell-mediated allergy to Ni(++) is one of the most common forms of allergic contact dermatitis, but how the T-cell receptor (TCR) recognizes Ni(++) is unknown. We studied a TCR from an allergic patient that recognizes Ni(++) bound to the MHCII molecule DR52c containing an unknown self-peptide. We identified mimotope peptides that can replace both the self-peptide and Ni(++) in this ligand. They share a p7 lysine whose εNH(2) group is surface-exposed when bound to DR52c. Whereas the TCR uses ge ...[more]