Ontology highlight
ABSTRACT:
SUBMITTER: Nishimura T
PROVIDER: S-EPMC3495171 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Molecular and cellular endocrinology 20090930 1-2
The secretion of the hormone insulin from beta cells is modulated by the expression of the dense core vesicle transmembrane protein IA-2. Since IA-2 is found in neuroendocrine cells throughout the body, the present experiments were initiated to determine whether the expression of IA-2 also modulates the secretion of neurotransmitters. Using the dopamine-secreting pheochromocytoma cell line PC12, we found that the overexpressions of IA-2 increased the cellular content and secretion of dopamine, w ...[more]