Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation.
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ABSTRACT:
SUBMITTER: Smith BR
PROVIDER: S-EPMC3495189 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation.
Smith Bryan Ronain BR Kempen Paul P Bouley Donna D Xu Alexander A Liu Zhuang Z Melosh Nicholas N Dai Hongjie H Sinclair Robert R Gambhir Sanjiv Sam SS
Nano letters 20120611 7
Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. ...[more]
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