Ontology highlight
ABSTRACT:
SUBMITTER: Brill A
PROVIDER: S-EPMC3495568 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Brill Alexander A Yesilaltay Ayce A De Meyer Simon F SF Kisucka Janka J Fuchs Tobias A TA Kocher Olivier O Krieger Monty M Wagner Denisa D DD
Arteriosclerosis, thrombosis, and vascular biology 20120531 8
<h4>Objective</h4>Deep vein thrombosis (DVT) and pulmonary embolism are frequent causes of morbidity and mortality. The goal of our study was to determine whether plasma high-density lipoprotein (HDL), which inversely correlates with the risk of cardiovascular events, affects DVT.<h4>Methods and results</h4>Using a murine DVT model of inferior vena cava stenosis, we demonstrated that deficiency of the HDL receptor, scavenger receptor class B type I (SR-BI), promotes venous thrombosis. As SR-BI(- ...[more]