Ontology highlight
ABSTRACT:
SUBMITTER: Slevin LK
PROVIDER: S-EPMC3496063 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20120920 11
Centrioles are key microtubule polarity determinants. Centriole duplication is tightly controlled to prevent cells from developing multipolar spindles, a situation that promotes chromosomal instability. A conserved component in the duplication pathway is Plk4, a polo kinase family member that localizes to centrioles in M/G1. To limit centriole duplication, Plk4 levels are controlled through trans-autophosphorylation that primes ubiquitination. In contrast to Plks 1-3, Plk4 possesses a unique cen ...[more]