Ontology highlight
ABSTRACT:
SUBMITTER: Goetz SC
PROVIDER: S-EPMC3496184 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Goetz Sarah C SC Liem Karel F KF Anderson Kathryn V KV
Cell 20121101 4
The primary cilium has critical roles in human development and disease, but the mechanisms that regulate ciliogenesis are not understood. Here, we show that Tau tubulin kinase 2 (TTBK2) is a dedicated regulator of the initiation of ciliogenesis in vivo. We identified a null allele of mouse Ttbk2 based on loss of Sonic hedgehog activity, a signaling pathway that requires the primary cilium. Despite a normal basal body template, Ttbk2 mutants lack cilia. TTBK2 acts at the distal end of the basal b ...[more]