Ontology highlight
ABSTRACT:
SUBMITTER: Li FF
PROVIDER: S-EPMC3496208 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Li Fen-Fen FF Shen Jian J Shen Hui-Juan HJ Zhang Xue X Cao Rui R Zhang Yun Y Qui Qiu Q Lin Xi-Xi XX Xie Yi-Cheng YC Zhang Lin-Hui LH Jia Yong-Liang YL Dong Xin-Wei XW Jiang Jun-Xia JX Bao Meng-Jing MJ Zhang Shanshan S Ma Wen-Jiang WJ Wu Xi-Mei XM Shen Huahao H Xie Qiang-Min QM Ke Yuehai Y
Journal of immunology (Baltimore, Md. : 1950) 20120813 6
Cigarette smoke (CS), the major cause of chronic obstructive pulmonary disease, contains a variety of oxidative components that were implicated in the regulation of Src homology domain 2-containing protein tyrosine phosphatase 2 (Shp2) activity. However, the contribution of Shp2 enzyme to chronic obstructive pulmonary disease pathogenesis remains unclear. We investigated the role of Shp2 enzyme in blockading CS-induced pulmonary inflammation. Shp2 levels were assessed in vivo and in vitro. Mice ...[more]