Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC3496343 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Yang Xin X Todd John A JA Clayton David D Wallace Chris C
Bioinformatics (Oxford, England) 20120912 22
<h4>Motivation</h4>The invention of next-generation sequencing technology has made it possible to study the rare variants that are more likely to pinpoint causal disease genes. To make such experiments financially viable, DNA samples from several subjects are often pooled before sequencing. This induces large between-pool variation which, together with other sources of experimental error, creates over-dispersed data. Statistical analysis of pooled sequencing data needs to appropriately model thi ...[more]