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PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study.


ABSTRACT: Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanation for the cough reflex hypersensitivity and pulmonary inflammation reported in chronic cough patients.Bronchoscopic endobronchial biopsies and bronchoalveolar lavage cell counts were obtained from ten healthy volunteers and twenty treatment resistant chronic cough patients (10 selected for lavage lymphocytosis). A screen for known respiratory pathogens was performed on biopsy tissue. Chronic cough patients also underwent cough reflex sensitivity testing using citric acid.There was no significant difference in incidence of infection between healthy volunteers and chronic cough patients (p?=?0.115) or non-lymphocytic and lymphocytic groups (p?=?0.404). BAL cell percentages were not significantly different between healthy volunteers and chronic cough patients without lymphocytosis. Lymphocytic patients however had a significantly raised percentage of lymphocytes (p?

SUBMITTER: West PW 

PROVIDER: S-EPMC3496690 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study.

West Peter W PW   Kelsall Angela A   Decalmer Samantha S   Dove Winifred W   Bishop Paul W PW   Stewart James P JP   Woodcock Ashley A AA   Smith Jaclyn A JA  

Cough (London, England) 20120914 1


<h4>Unlabelled</h4><h4>Background</h4>Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanation for the cough reflex hypersensitivity and pulmonary inflammation reported in chronic cough patients.<h4>Methods</h4>Bronchoscopic endobronchial biopsies and bronchoalveolar lavage cell counts were obtained from ten healthy volunteers and twenty treatm  ...[more]

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