Dataset Information

IL12RB2 gene is associated with the age of type 1 diabetes onset in Croatian family Trios.

ABSTRACT:

Background

Common complex diseases are influenced by both genetic and environmental factors. Many genetic factors overlap between various autoimmune diseases. The aim of the present study is to determine whether four genetic variants known to be risk variants for several autoimmune diseases could be associated with an increased susceptibility to type 1 diabetes mellitus.

Methods and findings

We genotyped four genetic variants (rs2358817, rs1049550, rs6679356, rs9865818) within VTCN1, ANXA11, IL12RB2 and LPP genes respectively, in 265 T1DM family trios in Croatian population. We did not detect association of these polymorphisms with T1DM. However, quantitative transmission disequilibrium test (QTDT, orthogonal model) revealed a significant association between the age of onset of T1DM and IL12RB2 rs6679356 variant. An earlier onset of T1DM was associated with the rs6679356 minor dominant allele C (p?=?0.005). The association remained significant even after the Bonferroni correction for multiple testing and permutation.

Conclusions

Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset. Nevertheless, association of IL12RB2 rs6679356 polymorphism with the age of T1DM onset suggests that this gene plays a role in defining the time of disease onset.

SUBMITTER: Pehlic M

PROVIDER: S-EPMC3496735 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

IL12RB2 gene is associated with the age of type 1 diabetes onset in Croatian family Trios.

Pehlić Marina M Vrkić Dina D Skrabić Veselin V Jerončić Ana A Stipančić Gordana G Urojić Anita Špehar AŠ Marjanac Igor I Jakšić Jasminka J Kačić Zrinka Z Boraska Vesna V Zemunik Tatijana T

PloS one 20121113 11

<h4>Background</h4>Common complex diseases are influenced by both genetic and environmental factors. Many genetic factors overlap between various autoimmune diseases. The aim of the present study is to determine whether four genetic variants known to be risk variants for several autoimmune diseases could be associated with an increased susceptibility to type 1 diabetes mellitus.<h4>Methods and findings</h4>We genotyped four genetic variants (rs2358817, rs1049550, rs6679356, rs9865818) within VTC ...[more]

PMID: 23152861

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Dataset Information

IL12RB2 gene is associated with the age of type 1 diabetes onset in Croatian family Trios.

Background

Methods and findings

Conclusions

Publications

IL12RB2 gene is associated with the age of type 1 diabetes onset in Croatian family Trios.

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