Ontology highlight
ABSTRACT:
SUBMITTER: Martens JH
PROVIDER: S-EPMC3496958 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Martens Joost H A JH Mandoli Amit A Simmer Femke F Wierenga Bart-Jan BJ Saeed Sadia S Singh Abhishek A AA Altucci Lucia L Vellenga Edo E Stunnenberg Hendrik G HG
Blood 20120914 19
ERG and FLI1 are closely related members of the ETS family of transcription factors and have been identified as essential factors for the function and maintenance of normal hematopoietic stem cells. Here genome-wide analysis revealed that both ERG and FLI1 occupy similar genomic regions as AML1-ETO in t(8;21) AMLs and identified ERG/FLI1 as proteins that facilitate binding of oncofusion protein complexes. In addition, we demonstrate that ERG and FLI1 bind the RUNX1 promoter and that shRNA-mediat ...[more]