Ontology highlight
ABSTRACT:
SUBMITTER: Salian S
PROVIDER: S-EPMC3497201 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Salian Sumantha S Matt Tanja T Akbergenov Rashid R Harish Shinde S Meyer Martin M Duscha Stefan S Shcherbakov Dmitri D Bernet Bruno B BB Vasella Andrea A Westhof Eric E Böttger Erik C EC
Antimicrobial agents and chemotherapy 20120904 12
The kanamycins form an important subgroup of the 4,6-disubstituted 2-deoxystreptamine aminoglycoside antibiotics, comprising kanamycin A, kanamycin B, tobramycin, and dibekacin. These compounds interfere with protein synthesis by targeting the ribosomal decoding A site, and they differ in the numbers and locations of amino and hydroxy groups of the glucopyranosyl moiety (ring I). We synthesized kanamycin analogues characterized by subtle variations of the 2' and 6' substituents of ring I. The fu ...[more]