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Preferential utilization of D-lactate by Shewanella oneidensis.


ABSTRACT: Shewanella oneidensis couples oxidation of lactate to respiration of many substrates. Here we report that llpR (L-lactate-positive regulator, SO_3460) encodes a positive regulator of L-lactate utilization distinct from previously studied regulators. We also demonstrate D-lactate inhibition of L-lactate utilization in S. oneidensis, resulting in preferential utilization of the D isomer.

SUBMITTER: Brutinel ED 

PROVIDER: S-EPMC3497373 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Preferential utilization of D-lactate by Shewanella oneidensis.

Brutinel Evan D ED   Gralnick Jeffrey A JA  

Applied and environmental microbiology 20120921 23


Shewanella oneidensis couples oxidation of lactate to respiration of many substrates. Here we report that llpR (L-lactate-positive regulator, SO_3460) encodes a positive regulator of L-lactate utilization distinct from previously studied regulators. We also demonstrate D-lactate inhibition of L-lactate utilization in S. oneidensis, resulting in preferential utilization of the D isomer. ...[more]

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