Ontology highlight
ABSTRACT:
SUBMITTER: Varvel NH
PROVIDER: S-EPMC3497743 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Varvel Nicholas H NH Grathwohl Stefan A SA Baumann Frank F Liebig Christian C Bosch Andrea A Brawek Bianca B Thal Dietmar R DR Charo Israel F IF Heppner Frank L FL Aguzzi Adriano A Garaschuk Olga O Ransohoff Richard M RM Jucker Mathias M
Proceedings of the National Academy of Sciences of the United States of America 20121015 44
Under most physiological circumstances, monocytes are excluded from parenchymal CNS tissues. When widespread monocyte entry occurs, their numbers decrease shortly after engraftment in the presence of microglia. However, some disease processes lead to focal and selective loss, or dysfunction, of microglia, and microglial senescence typifies the aged brain. In this regard, the long-term engraftment of monocytes in the microglia-depleted brain remains unknown. Here, we report a model in which a nic ...[more]