Ontology highlight
ABSTRACT:
SUBMITTER: Uckun FM
PROVIDER: S-EPMC3497833 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Uckun Fatih M FM Ma Hong H Zhang Jian J Ozer Zahide Z Dovat Sinisa S Mao Cheney C Ishkhanian Rita R Goodman Patricia P Qazi Sanjive S
Proceedings of the National Academy of Sciences of the United States of America 20121015 44
Ikaros is a zinc finger-containing DNA-binding protein that plays a pivotal role in immune homeostasis through transcriptional regulation of the earliest stages of lymphocyte ontogeny and differentiation. Functional deficiency of Ikaros has been implicated in the pathogenesis of acute lymphoblastic leukemia, the most common form of childhood cancer. Therefore, a stringent regulation of Ikaros activity is considered of paramount importance, but the operative molecular mechanisms responsible for i ...[more]