Ontology highlight
ABSTRACT:
SUBMITTER: Bunker RD
PROVIDER: S-EPMC3497992 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Bunker Richard D RD Dickson James M J JM Caradoc-Davies Tom T TT Loomes Kerry M KM Baker Edward N EN
Acta crystallographica. Section F, Structural biology and crystallization communications 20120929 Pt 10
In mammals, the enzyme D-xylulokinase (XK; EC 2.7.1.17) catalyses the last step of the glucuronate-xylulose pathway, in which the ketopentose sugar D-xylulose is phosphorylated to yield D-xylulose 5-phosphate (Xu5P). Xu5P is also a metabolite of the pentose phosphate pathway and acts as a signalling molecule that regulates lipogenesis and glycolysis in the liver. To date, no eukaryotic XK has been structurally characterized. A putative human XK was expressed in Escherichia coli aided by molecula ...[more]