Ontology highlight
ABSTRACT:
SUBMITTER: Unger WW
PROVIDER: S-EPMC3498321 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Unger Wendy W J WW Pearson Todd T Abreu Joana R F JR Laban Sandra S van der Slik Arno R AR der Kracht Sacha Mulder-van SM Kester Michel G D MG Serreze Dave V DV Shultz Leonard D LD Griffioen Marieke M Drijfhout Jan Wouter JW Greiner Dale L DL Roep Bart O BO
PloS one 20121114 11
Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role in-vivo is lacking. To address a destructive role for autoreactive CD8 T-cells in human disease, we assessed the pathogenicity of a CD8 T-cell clone derived from a T1D donor and specific for an HLA-A2-restricted epitope of islet-specific glucose-6-phosphatase catalytic-subunit related protein (IGRP). H ...[more]