Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant ?-synuclein.
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ABSTRACT:
SUBMITTER: Griffioen KJ
PROVIDER: S-EPMC3498580 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.
Griffioen Kathleen J KJ Rothman Sarah M SM Ladenheim Bruce B Wan Ruiqian R Vranis Neil N Hutchison Emmette E Okun Eitan E Cadet Jean Lud JL Mattson Mark P MP
Neurobiology of aging 20120809 3
Parkinson's disease (PD) patients often exhibit impaired regulation of heart rate by the autonomic nervous system (ANS) that may precede motor symptoms in many cases. Results of autopsy studies suggest that brainstem pathology, including the accumulation of α-synuclein, precedes damage to dopaminergic neurons in the substantia nigra in PD. However, the molecular and cellular mechanisms responsible for the early dysfunction of brainstem autonomic neurons are unknown. Here we report that mice expr ...[more]
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