Ontology highlight
ABSTRACT:
SUBMITTER: Mendoza JL
PROVIDER: S-EPMC3498824 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Mendoza Juan L JL Schmidt André A Thomas Philip J PJ
Methods in molecular biology (Clifton, N.J.) 20110101
Inefficient folding of CFTR into a functional three-dimensional structure is the basic pathophysiologic mechanism leading to most cases of cystic fibrosis. Knowledge of the structure of CFTR and placement of these mutations into a structural context would provide information key for developing targeted therapeutic approaches for cystic fibrosis. As a large polytopic membrane protein containing disordered regions, intact CFTR has been refractory to efforts to solve a high-resolution structure usi ...[more]