Ontology highlight
ABSTRACT:
SUBMITTER: Franceschi E
PROVIDER: S-EPMC3499012 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Franceschi Enrico E Stupp Roger R van den Bent Martin J MJ van Herpen Carla C Laigle Donadey Florence F Gorlia Thierry T Hegi Monika M Lhermitte Benoit B Strauss Lewis C LC Allgeier Anouk A Lacombe Denis D Brandes Alba A AA
Neuro-oncology 20121022 12
The treatment of patients with recurrent glioblastoma remains a major oncologic problem, with median survival after progression of 7-9 months. To determine the maximum tolerated dose and dose-limiting toxicity (DLT), the combination of dasatinib and cyclonexyl-chloroethyl-nitrosourea (CCNU) was investigated in this setting. The study was designed as multicenter, randomized phase II trial, preceded by a lead-in safety phase. The safety component reported here, which also investigated pharmacokine ...[more]