Ontology highlight
ABSTRACT:
SUBMITTER: Crielaard BJ
PROVIDER: S-EPMC3499037 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20120612 29
Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models. ...[more]