Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.
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ABSTRACT:
SUBMITTER: Ji F
PROVIDER: S-EPMC3499047 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
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Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.
Ji Fang F Wang Wei W Xia Zhao-Lin ZL Zheng Ying-Jia YJ Qiu Yu-Lan YL Wu Fen F Miao Wen-Bin WB Jin Ru-Feng RF Qian Ji J Jin Li L Zhu Yi-Liang YL Christiani David C DC
Carcinogenesis 20100125 4
Vinyl chloride (VC) was classified as a group 1 carcinogen by IARC in 1987. Although the relationship between VC exposure and liver cancer has been established, the mechanism of VC-related carcinogenesis remains largely unknown. Previous epidemiological studies have shown that VC exposure is associated with increased genotoxicity in humans. To explore chromosomal damage and its progression, and their association to genetic susceptibility, we investigated 402 workers exposed to VC, a 77 VC-expose ...[more]
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