Ontology highlight
ABSTRACT:
SUBMITTER: di Bari MG
PROVIDER: S-EPMC3499107 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
di Bari Maria Giovanna MG Lutsiak M E Christine ME Takai Shinji S Mostböck Sven S Farsaci Benedetto B Semnani Roshanak Tolouei RT Wakefield Lalage M LM Schlom Jeffrey J Sabzevari Helen H
Cancer immunology, immunotherapy : CII 20090325 11
This study demonstrates that CD8+ T cells in the tumor microenvironment display reduced functionality and hyporesponsiveness. TGF-beta contributed markedly to the tumor-infiltrating CD8+ T cells' (TILs) reduced functionality, which could be reversed using a small molecule TGF-beta inhibitor. Upon T-cell receptor (TCR) activation, the activation of ITK and ERK kinases were reduced in CD8+ TILs, as compared to splenic CD8+ T cells: TGF-beta inhibitor could reverse this phenomenon. This study demon ...[more]