Dataset Information

Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

ABSTRACT:

Objectives

To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses.

Methods

The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years.

Results

Patients reaching clinically definite multiple sclerosis showed impaired recovery of neurological function, faster decrease in corpus callosum cross-sectional area, higher T2 lesion volume and more contrast-enhancing lesions. Six-month decrease in corpus callosum cross-sectional area (? 1%) and baseline T2 lesion volume (? 5 cm(3)) predicted clinically definite multiple sclerosis within 2 years (hazard ratios 2.5 and 1.8, respectively). Of 22 patients fulfilling both predictive criteria, 83% reached clinically definite multiple sclerosis (hazard ratio 6.5). More relapses were associated with poorer recovery of neurological function and accelerated brain atrophy.

Conclusions

Neurological impairment is more permanent, brain atrophy is accelerated and focal inflammatory activity is greater in patients converting to clinically definite multiple sclerosis. Six-month corpus callosum atrophy and baseline T2 lesion volume jointly help predict individual risk of clinically definite multiple sclerosis. Early relapses contribute to permanent damage of the central nervous system.

SUBMITTER: Kalincik T

PROVIDER: S-EPMC3499512 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

Kalincik Tomas T Vaneckova Manuela M Tyblova Michaela M Krasensky Jan J Seidl Zdenek Z Havrdova Eva E Horakova Dana D

PloS one 20121115 11

<h4>Objectives</h4>To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses.<h4>Methods</h4>The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were e ...[more]

PMID: 23166826

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Dataset Information

Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

Objectives

Methods

Results

Conclusions

Publications

Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study.

Similar Datasets

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