Conservation of the three-dimensional structure in non-homologous or unrelated proteins.
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ABSTRACT:
SUBMITTER: Sousounis K
PROVIDER: S-EPMC3500211 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Conservation of the three-dimensional structure in non-homologous or unrelated proteins.
Sousounis Konstantinos K Haney Carl E CE Cao Jin J Sunchu Bharath B Tsonis Panagiotis A PA
Human genomics 20120802
In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence. ...[more]
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