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Biomimetic synthesis and biological evaluation of Aplidiopsamine A.

ABSTRACT: The first total synthesis of Aplidiopsamine A, a rare 3H-pyrrolo[2,3-c]quinoline alkaloid from the Aplidiopsis confluata, has been achieved following the proposed biosynthesis. This biomimetic synthesis requires only five steps and proceeds in 20.8% overall yield. Biological evaluation across large panels of discrete molecular targets identified that Aplidiopsamine A is a highly selective PDE4 inhibitor, a target for numerous CNS disorders.

SUBMITTER: Panarese JD

PROVIDER: S-EPMC3500438 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Biomimetic synthesis and biological evaluation of Aplidiopsamine A.

Panarese Joseph D JD Lindsley Craig W CW

Organic letters 20121029 22

The first total synthesis of Aplidiopsamine A, a rare 3H-pyrrolo[2,3-c]quinoline alkaloid from the Aplidiopsis confluata, has been achieved following the proposed biosynthesis. This biomimetic synthesis requires only five steps and proceeds in 20.8% overall yield. Biological evaluation across large panels of discrete molecular targets identified that Aplidiopsamine A is a highly selective PDE4 inhibitor, a target for numerous CNS disorders. ...[more]

PMID: 23106227

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