Ontology highlight
ABSTRACT:
SUBMITTER: Mouneimne G
PROVIDER: S-EPMC3500527 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20121101 5
Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin polymerization; however, functional differences among coexpressed profilin isoforms are not well defined. Here, we demonstrate that profilin-1 and profilin-2 differentially regulate membrane protrusion, motility, and invasion; these processes are promoted by profilin-1 and suppressed by profilin-2. Compared to profilin-1, profilin-2 preferentially drives actin polymerizati ...[more]