Ontology highlight
ABSTRACT:
SUBMITTER: Croteau DL
PROVIDER: S-EPMC3500627 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Croteau Deborah L DL Singh Dharmendra Kumar DK Hoh Ferrarelli Leslie L Lu Huiming H Bohr Vilhelm A VA
Trends in genetics : TIG 20120830 12
Helicases are ubiquitous proteins that unwind DNA and participate in DNA metabolism including replication, repair, transcription, and chromatin organization. The highly conserved RecQ helicase family proteins are important in these transactions and have been termed the guardians of the genome. Humans have five members of this family: WRN, BLM, RECQL4, RECQL1, and RECQL5. The first three of are associated with premature aging and cancer prone syndromes, but the latter two proteins have not yet be ...[more]