Ontology highlight
ABSTRACT:
SUBMITTER: Zonta F
PROVIDER: S-EPMC3500697 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Zonta Francesco F Polles Guido G Zanotti Giuseppe G Mammano Fabio F
Journal of biomolecular structure & dynamics 20120101 5
Mutations in the genes GJB2 and GJB6 encoding human connnexin26 (hCx26) and connexin30 (hCx30), respectively, are the leading cause of non-syndromic prelingual deafness in several human populations. In this work, we exploited the high degree (77%) of sequence similarity shared by hCx26 and hCx30 to create atomistic models of homomeric hCx26 and hCx30 connexons starting from the X-ray crystallographic structure of an intercellular channel formed by hCx26 protomers at 3.5-å resolution. The equilib ...[more]