Ontology highlight
ABSTRACT:
SUBMITTER: Lee MJ
PROVIDER: S-EPMC3501264 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Lee Michael J MJ Ye Albert S AS Gardino Alexandra K AK Heijink Anne Margriet AM Sorger Peter K PK MacBeath Gavin G Yaffe Michael B MB
Cell 20120501 4
Crosstalk and complexity within signaling pathways and their perturbation by oncogenes limit component-by-component approaches to understanding human disease. Network analysis of how normal and oncogenic signaling can be rewired by drugs may provide opportunities to target tumors with high specificity and efficacy. Using targeted inhibition of oncogenic signaling pathways, combined with DNA-damaging chemotherapy, we report that time-staggered EGFR inhibition, but not simultaneous coadministratio ...[more]