Ontology highlight
ABSTRACT:
SUBMITTER: Bierings R
PROVIDER: S-EPMC3501642 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Bierings Ruben R Hellen Nicola N Kiskin Nikolai N Knipe Laura L Fonseca Ana-Violeta AV Patel Bijal B Meli Athina A Rose Marlene M Hannah Matthew J MJ Carter Tom T
Blood 20120816 13
Weibel-Palade body (WPB) exocytosis underlies hormone-evoked VWF secretion from endothelial cells (ECs). We identify new endogenous components of the WPB: Rab3B, Rab3D, and the Rab27A/Rab3 effector Slp4-a (granuphilin), and determine their role in WPB exocytosis. We show that Rab3B, Rab3D, and Rab27A contribute to Slp4-a localization to WPBs. siRNA knockdown of Slp4-a, MyRIP, Rab3B, Rab3D, Rab27A, or Rab3B/Rab27A, or overexpression of EGFP-Slp4-a or EGFP-MyRIP showed that Slp4-a is a positive an ...[more]