Lack of methylation in the upstream region of human papillomavirus type 6 from aerodigestive tract papillomas.
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ABSTRACT:
SUBMITTER: Ure AE
PROVIDER: S-EPMC3503112 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Lack of methylation in the upstream region of human papillomavirus type 6 from aerodigestive tract papillomas.
Ure Agustín Enrique AE Forslund Ola O
Journal of virology 20121003 24
Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the URR were unmethylated, from both basal/intermediate and superficial cells, suggesting that methylation is not involved in the regulation of transcription from the HPV6 URR, r ...[more]
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