A novel multi-scale modeling approach to infer whole genome divergence.
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ABSTRACT:
SUBMITTER: Reuveni E
PROVIDER: S-EPMC3503470 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
A novel multi-scale modeling approach to infer whole genome divergence.
Reuveni Eli E Giuliani Alessandro A
Evolutionary bioinformatics online 20121114
We propose a novel and simple approach to elucidate genomic patterns of divergence using principal component analysis (PCA). We applied this methodology to the metric space generated by M. musculus genome-wide SNPs. Distance profiles were computed between M. musculus and its closely related species, M. spretus, which was used as external reference. While the speciation dynamics were apparent in the first principal component, the within M. musculus differentiation dimensions gave rise to three mi ...[more]
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