De novo origin of protein-coding genes in murine rodents.

ABSTRACT:

Background

New genes in eukaryotes are created through a variety of different mechanisms. De novo origin from non-coding DNA is a mechanism that has recently gained attention. So far, de novo genes have been described in a handful of organisms, with Drosophila being the most extensively studied. We searched for genes that have appeared de novo in the mouse and rat lineages.

Methodology

Using a rigorous and conservative approach we identify 75 murine genes (69 mouse genes and 6 rat genes) for which there is good evidence of de novo origin since the divergence of mouse and rat. Each of these genes is only found in either the mouse or rat lineages, with no candidate orthologs nor evidence for potentially-unannotated orthologs in the other lineage. The veracity of each of these

SUBMITTER: Murphy DN 

PROVIDER: S-EPMC3504067 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature