Ontology highlight
ABSTRACT:
SUBMITTER: Drullion C
PROVIDER: S-EPMC3504262 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Leukemia research and treatment 20120223
We used K562 cells sensitive or generated resistant to imatinib or nilotinib to investigate their response to mycophenolic acid (MPA). MPA induced DNA damage leading to cell death with a minor contribution of apoptosis, as revealed by annexin V labeling (up to 25%). In contrast, cell cycle arrest and positive staining for senescence-associated β-galactosidase activity were detected for a large cell population (80%). MPA-induced cell death was potentialized by the inhibition of autophagy and this ...[more]