Rings in the extreme: PCNA interactions and adaptations in the archaea.
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ABSTRACT:
SUBMITTER: Winter JA
PROVIDER: S-EPMC3504372 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Rings in the extreme: PCNA interactions and adaptations in the archaea.
Winter Jody A JA Bunting Karen A KA
Archaea (Vancouver, B.C.) 20121114
Biochemical and structural analysis of archaeal proteins has enabled us to gain great insight into many eukaryotic processes, simultaneously offering fascinating glimpses into the adaptation and evolution of proteins at the extremes of life. The archaeal PCNAs, central to DNA replication and repair, are no exception. Characterisation of the proteins alone, and in complex with both peptides and protein binding partners, has demonstrated the diversity and subtlety in the regulatory role of these s ...[more]
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