Twist-joints and double twist-joints in RNA structure.
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ABSTRACT:
SUBMITTER: Boutorine YI
PROVIDER: S-EPMC3504679 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Twist-joints and double twist-joints in RNA structure.
Boutorine Yury I YI Steinberg Sergey V SV
RNA (New York, N.Y.) 20121011 12
Analysis of available RNA crystal structures has allowed us to identify a new family of RNA arrangements that we call double twist-joints, or DTJs. Each DTJ is composed of a double helix that contains two bulges incorporated into different strands and separated from each other by 2 or 3 bp. At each bulge, the double helix is over-twisted, while the unpaired nucleotides of both bulges form a complex network of stacking and hydrogen-bonding with nucleotides of helical regions. In total, we identif ...[more]
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