Inhibitory glycine receptors: an update.
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ABSTRACT:
SUBMITTER: Dutertre S
PROVIDER: S-EPMC3504737 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Inhibitory glycine receptors: an update.
Dutertre Sébastien S Becker Cord-Michael CM Betz Heinrich H
The Journal of biological chemistry 20121004 48
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR isoforms. GlyRs not only regulate the excitability of motor and afferent sensory neurons, including pain fibers, but also are involved in the proces ...[more]
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