Ontology highlight
ABSTRACT:
SUBMITTER: Kemal KS
PROVIDER: S-EPMC3505048 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Kemal Kimdar S KS Ramirez Christina M CM Burger Harold H Foley Brian B Mayers Douglas D Klimkait Thomas T Hamy François F Anastos Kathryn K Petrovic Katarina K Minin Vladimir N VN Suchard Marc A MA Weiser Barbara B
AIDS research and human retroviruses 20120410 12
Multidrug-resistant (MDR) HIV-1 presents a challenge to the efficacy of antiretroviral therapy (ART). To examine mechanisms leading to MDR variants in infected individuals, we studied recombination between single viral genomes from the genital tract and plasma of a woman initiating ART. We determined HIV-1 RNA sequences and drug resistance profiles of 159 unique viral variants obtained before ART and semiannually for 4 years thereafter. Soon after initiating zidovudine, lamivudine, and nevirapin ...[more]